产品货号：
Z11101
中文名称：
APEX1抗体
英文名称：
Anti-APEX1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-APEX1 Antibody |
| 指标别名 | AP endonuclease 1;APE;APE1;APE1;APEX1;APEN;APEX;APEX nuclease;APEX1;APX;HAP1;Protein REF 1;REF1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IF,ICC/IF,FCM |
| 基因名称 | APEX1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human APE1 recombinant protein (Position:P2-L318).Human APE1 shares 94% and 93% amino acid (aa) sequences identity with mouse and rat APE1,respectively. |
| 实际分子量 | 39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | APEX1,also called apurinic endonuclease (APE),is a DNA repair enzyme having apurinic/apyrimidinic (AP) endonuclease,3-prime,5-prime-exonuclease,DNA 3-prime repair diesterase,and DNA 3-prime-phosphatase activities.The human APEX1 gene consists of 5 exons spanning 2.64kb and exists as a single copy in the haploid genome.Using in situ hybridization,the APEX1 gene is mapped to 14q11.2-q12.The predicted APEX1 protein,which contained probable nuclear transport signals,was identified as a member of a family of DNA repair enzymes found in lower organisms.The abundance of the large form of APEX1 was increased in leiomyoma extracts relative to myometrial tissue extracts,and the large form was dominant in cell lines derived from leiomyosarcomas.The exonuclease activity of nuclear APEX1 can remove the anti-HIV nucleoside analogs AZT and D4T from the 3-prime terminus of a nick more efficiently than can cytosolic exonucleases. |
| Uniprot ID | P27695 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | APEX nuclease (multifunctional DNA repair enzyme) 1 |
| 蛋白名全称 | DNA-(apurinic or apyrimidinic site) lyase |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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